diffusion tensor imaging of the cervical spinal cord of patients with relapsing-remising multiple sclerosis: a study of 41 cases imagens por tensor de difusão da medula cervical de pacientes com esclerose múltipla remitente-recorrente: estudo de 41 casos

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ID: 203169
2009
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Abstract
OBJECTIVE: To evaluate the fractional anisotropy (FA) values of the multiple sclerosis (MS) plaques and normal-appearing cervical spinal cord (NASC) by diffusion tensor MRI imaging (DTI). METHOD: Forty-one patients with relapsing-remising MS and 37 controls were evaluated. All MRI exams were performed using a conventional protocol, as well as diffusion tensor MR imaging. Regions of interest were placed within the spinal cord lesions and in the normal appearing spinal cord adjacent to the plaque. RESULTS: The FA values were statistically reduced in the plaques compared to the surrounding NASC and to equivalent location in controls. A reduction in FA values was also observed in the spinal cord of MS patients without visible lesions on T2WI. CONCLUSION: We observed reduced fractional anisotropy in the demyelinating plaques and in the NASC of MS patients, corroborating the hypothesis that the histological extension of the MS lesions is more severe than the abnormalities seen in the conventional MRI sequences.
OBJETIVO: Avaliar os valores da anisotropia fracionada (FA) em pacientes com esclerose múltipla (EM) nas placas e na medula espinhal aparentemente normal (MEAN). MÉTODO: Quarenta e um pacientes com EM remitente-recorrente e 37 controles foram examinados. Todos os exames foram realizados com protocolo convencional, assim como imagens por tensor de difusão. Regiões de interesse foram definidas nas placas da medula espinhal e na MEAN ao redor das placas. RESULTADOS: Os valores de FA estavam significativamente reduzidos nas placas, comparados à MEAN ao redor e às regiões equivalentes dos controles. Redução dos valores de FA também foi demonstrada na medula espinhal de pacientes com EM sem lesões visíveis nas imagens de RM pesadas em T2. CONCLUSÃO: Observamos redução dos valores de anisotropia fracionada nas placas de desmielinização e na MEAN, corroborando a hipótese de que a extensão histológica das lesões na EM é maior que as alterações de sinal vistas nas seqüências convencionais de ressonância magnética.
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jr.2009arquivosdiffusion Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;L. Celso Hygino Cruz Jr.;Romeu C. Domingues;Emerson L. Gasparetto
Journal communications in computer and information science
Year 2009
DOI
10.1590/S0004-282X2009000300004
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000300004
Keywords
Magnetic resonance imaging multiple sclerosis neuropsychiatry biological psychiatry

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