severe pigmented keratitis caused by cladorrhinum bulbillosum

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ID: 203021
2011
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Ranked #115 of 129 articles by views in bjog : an international journal of obstetrics and gynaecology

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Abstract
We report a case of severe pigmented keratitis with poor prognosis, caused by Cladorrhinum bulbillosum. Antifungal treatment with topical natamycin and fluconazole eye drops and oral tablet fluconazole failed to heal the ulcer and resulted in perforation. The causative fungus, C. bulbillosum, was identified on the basis of its typical microscopic features and 98% sequence homology to ex-type isolate CBS 304.90 (accession no. FM955448). The results of an in vitro antifungal susceptibility test indicated that the isolate was susceptible to natamycin, amphotericin B, fluconazole and itraconazole. The present case is the third case of keratitis and the second case of human keratitis. Compromised immunity due to liver cirrhosis could lead to a failed prognosis even when the fungal isolate is highly susceptible to antifungal treatment.
Reference Key
gajjar2011indiansevere Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;D U Gajjar;A K Pal;J M Santos;B K Ghodadra;A R Vasavada
Journal bjog : an international journal of obstetrics and gynaecology
Year 2011
DOI
10.4103/0255-0857.90191
URL
http://www.ijmm.org/article.asp?issn=0255-0857;year=2011;volume=29;issue=4;spage=434;epage=437;aulast=Gajjar
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