shh protein variance in the limb bud is constrained by feedback regulation and correlates with altered digit patterning

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ID: 202905
2017
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Abstract
mRNA variance has been proposed to play key roles in normal development, population fitness, adaptability, and disease. While variance in gene expression levels may be beneficial for certain cellular processes, for example in a cell’s ability to respond to external stimuli, variance may be detrimental for the development of some organs. In the bilaterally symmetric vertebrate limb buds, the amount of Sonic Hedgehog (SHH) protein present at specific stages of development is essential to ensure proper patterning of this structure. To our surprise, we found that SHH protein variance is present during the first 10 hr of limb development. The variance is virtually eliminated after the first 10 hr of limb development. By examining mutant animals, we determined that the ability of the limb bud apical ectodermal ridge (AER) to respond to SHH protein was required for reducing SHH variance during limb formation. One consequence of the failure to eliminate variance in SHH protein was the presence of polydactyly and an increase in digit length. These data suggest a potential novel mechanism in which alterations in SHH variance during evolution may have driven changes in limb patterning and digit length.
Reference Key
zhang2017g3:shh Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rui Zhang;Chanmi Lee;Lisa Y. Lawson;Lillian J. Svete;Lauren M. McIntyre;Brian D. Harfe
Journal separation and purification technology
Year 2017
DOI
10.1534/g3.116.033019
URL
http://g3journal.org/lookup/doi/10.1534/g3.116.033019
Keywords Keywords not found

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