deficiency of macrophage migration inhibitory factor (mif) inhibits cytokine-induced il-1β generation in murine pancreatic islet cells
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2013
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Abstract
In diabetes, pancreatic islets are subjected to high levels of inflammatory mediators that can lead to beta cell destruction. We recently showed that pancreatic islet cells derived from MIF-deficient (MIF-KO) mice are resistant to apoptosis induction by the cytotoxic stimuli of cytokines. Here we show that MIF-KO islets under cytokine (IFN-γ+TNF- α+IL-1β) stimulation express and secrete significantly lower amounts of IL-1β, while the expression of caspase-1 mRNA is not influenced by MIF deficiency. These data suggest that MIF-KO islets possess an innate defect in the process of IL-1 β synthesis and secretion.
| Reference Key |
ivana2013archivesdeficiency
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| Authors | ;Stojanović Ivana;Saksida Tamara;Stošić-Grujičić Stanislava |
| Journal | gastrointestinal endoscopy |
| Year | 2013 |
| DOI |
10.2298/ABS1301009S
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| URL | |
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