therapeutic effect of glucocorticoid inhalation for pulmonary fibrosis in ards patients

ARDS hastalarında pulmoner fibrozis tedavisinde glukokortikoid inhalasyonunun terapötik etkisi

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ID: 202352
2014
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Abstract
Objective　To observe the effect of glucocorticoid inhalation on the clinical symptoms and pulmonary fibrosis index in ARDS patients. Methods　Fifty-three ARDS patients admitted to ICU of Songjiang District Center Hospital of Shanghai from Dec. 2011 to Jun. 2013 were randomly divided into two groups. Group A (n=29) received conventional therapy, and group B (n=24) was given glucocorticoid inhalation treatment (budesonide, 2 mg, 1/12 h, for 12 days) on the basis of the conventional therapy. The oxygenation index, time of extubation, changes in pulmonary fibrosis index, including collagen Ⅰ(Co Ⅰ), Ⅲ procollagen peptide (PⅢP) and transforming growth factor (TGF-β1) were compared between the two groups, and the incidence of common adverse reactions were analyzed. Results　The oxygenation index of patients in group B was significantly improved on the 15th day compared with group A (P<0.05). There was a significant difference in the level of Co I, PⅢP and TGF-β1 between two groups as measured with enzyme-linked immunosorbent assay (P<0.05). The hormone therapy did not increase adverse effects (P>0.05). Conclusion　A small dose of glucocorticoids introduced by inhalation can improve the oxygenation index and pulmonary fibrosis level without increasing common adverse reactions, suggesting that the inhalation of corticosteroid may be a clinically safe and effective way in patients with ARDS. DOI: 10.11855/j.issn.0577-7402.2014.09.13
Amaç　Glukokortikoid inhalasyonunun ARDS hastalarında klinik semptomlar ve pulmoner fibrozis indeksi üzerindeki etkisini gözlemlemek. Yöntemler　Aralık 2011 ile Haziran 2013 tarihleri arasında Şanghay Songjiang Bölge Merkez Hastanesi Yoğun Bakım Ünitesine kabul edilen elli üç ARDS hastası rastgele iki gruba ayrıldı. Grup A (n=29) konvansiyonel tedavi alırken, Grup B'ye (n=24) konvansiyonel tedaviye ek olarak glukokortikoid inhalasyon tedavisi (budesonid, 2 mg, 12 saatte bir, 12 gün boyunca) uygulandı. İki grup arasında oksijenasyon indeksi, ekstübasyon zamanı, kollajen Ⅰ (Co Ⅰ), prokollajen Ⅲ peptidi (PⅢP) ve transforme edici büyüme faktörü (TGF-β1) dahil olmak üzere pulmoner fibrozis indeksindeki değişiklikler karşılaştırıldı ve yaygın advers reaksiyonların insidansı analiz edildi. Bulgular　Grup B'deki hastaların oksijenasyon indeksi 15. günde Grup A'ya kıyasla anlamlı derecede düzelme gösterdi (P<0,05). Enzim bağlı immünosorbent deneyi ile ölçülen Co I, PⅢP ve TGF-β1 düzeyleri açısından iki grup arasında anlamlı bir fark bulundu (P<0,05). Hormon tedavisi advers etkileri artırmadı (P>0,05). Sonuç　İnhalasyon yoluyla uygulanan düşük doz glukokortikoidler, yaygın advers reaksiyonları artırmaksızın oksijenasyon indeksini ve pulmoner fibrozis düzeyini iyileştirebilmektedir; bu durum kortikosteroid inhalasyonunun ARDS'li hastalarda klinik açıdan güvenli ve etkili bir yöntem olabileceğini düşündürmektedir. DOI: 10.11855/j.issn.0577-7402.2014.09.13
Reference Key
zhao2014medicaltherapeutic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Wen-biao ZHAO;Sheng-xia WAN;De-fang GU;Bin SHI
Journal frontiers in neurorobotics
Year 2014
DOI
DOI not found
URL
http://www.plamj.org/index.php/plamj/article/view/1009
Keywords
pulmonary fibrosis respiratory distress syndrome adult

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