Biocompatible carbon dots derived from κ-carrageenan and phenyl boronic acid for dual modality sensing platform of sugar and its anti-diabetic drug release behavior.

基于κ-卡拉胶和苯硼酸的生物相容性碳点用于糖的双模态传感平台及其抗糖尿病药物释放行为

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2019
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Abstract
Detection of sugar by enzymatic assay has been suffering from costly, time-taking, instable and denaturation of glucose oxidase. Recently, chemosensors that have affinity towards boronate became the hot topic in the domain of monosaccharide detection. In this work, a novel strategy was addressed to fabricate carbon dots (C-dots) from linear sulfated polysaccharides κ- carrageenan and phenyl boronic acid for nonenzymatic monosaccharide (glucose) detection. The boronic acid group anchored C-dots surface can form assembly by covalently bonded with the cis-diol moiety of the glucose which caused fluorescence quenching of the C-dots. The inert surface nature of the luminescent C-dots enables them to sense as low as 1.7 μM glucose without the interference of other biomolecules. The proposed sensing system was successfully applied for assay of glucose in blood serum. Interestingly, these C-dots were used as a nano vehicle for delivery of anti-diabetic drug Metformin. Good biocompatibility results were found with MTT and hemolysis assay. Owing to its simplicity and effectiveness, the as-prepared C-dots offered great promise for blood sugar diagnosis and treatment.
基于酶法的糖类检测一直受到成本高、耗时长、不稳定性以及葡萄糖氧化酶易变性等问题的困扰。近年来，具有硼酸亲和特性的化学传感器已成为单糖检测领域的研究热点。在本研究中，提出了一种以线性硫酸化多糖κ-卡拉胶和苯硼酸为原料制备碳点（C-dots）的新策略，用于非酶单糖（葡萄糖）的检测。锚定在碳点表面的硼酸基团可通过与葡萄糖的顺式二醇基团共价结合形成组装体，进而引起碳点的荧光猝灭。该发光碳点的惰性表面特性使其能够在免受其他生物分子干扰的情况下，检测低至 1.7 μM 的葡萄糖。所构建的传感系统已成功应用于血清中葡萄糖的测定。值得注意的是，这些碳点还被用作递送抗糖尿病药物二甲双胍的纳米载体。MTT和溶血实验结果表明其具有良好的生物相容性。凭借其简便性与高效性，所制备的碳点在血糖的诊断与治疗中展现出广阔的应用前景。
Reference Key
das2019biocompatibleinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Das, Poushali;Maity, Priti Prasanna;Ganguly, Sayan;Ghosh, Sabyasachi;Baral, Joydeep;Bose, Madhuparna;Choudhary, Sumita;Gangopadhyay, Subhashis;Dhara, Santanu;Das, Amit Kumar;Banerjee, Susanta;Das, Narayan Chandra;
Journal International journal of biological macromolecules
Year 2019
DOI
S0141-8130(19)30986-9
URL
Keywords Keywords not found

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