evaluating the effect of bleomycin sulfate on oral keratotic lesions
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ID: 201342
1997
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Abstract
Non-removable Keratotic lesions are relatively
prevalent in various types in oral mucosa. The treatment modality is often
problematic and is done by using various
specific regimens. Bleomycin was used in two primary studies with limited
number of patients (N=9) . In current survey, more patients were recruited in a
longer period of study. In fact, 50 leukoplakia and lichen planus patients were
treated by local administration of belomycin
in a 21 months follow-up period. Statistical analysis was done by using
Kaplan meier and cox Regression methods. The obtained results showed that
belomycin can remove many of these lesions and can prevent both chronic pattern
and malignant changes of the lesions. As In 9 cases of leukoplakia, 2 cases of
recurrence were recorded. According to statistical analysis, in case of
complete treatment up to 11 months , the recurrence would not be possible. In 41 cases of lichen
planus, recurrence rate was higher and after
a longer period (17 months ) following complete treatment, recurrence
was totally eliminated. In fact, Recurrence can be due to psychological conditions.
To conclude, local administration of Bleomycin is recommended to use to treat
Oral keratotic lesions and can act
successfully based on current study's findings.
| Reference Key |
1997journalevaluating
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| Authors | ;E. Yazdi ;F. Agha hoseini |
| Journal | american journal of alzheimer's disease and other dementias |
| Year | 1997 |
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