systems approach to the study of brain damage in the very preterm newborn

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ID: 201234
2015
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Abstract
Background: A systems approach to the study of brain damage in very preterm newborns has been lackingMethods: In this perspective piece, we offer encephalopathy of prematurity as an example of the complexity and interrelatedness of brain-damaging molecular processes that can be initiated inflammatory phenomena. Results: Using three transcription factors, nuclear factor-kappa B (NF-κB), Notch-1, and nuclear factor erythroid 2 related factor 2 (NRF2), we show the inter-connectedness of signaling pathways activated by some antecedents of encephalopathy of prematurity. Conclusions: We hope that as biomarkers of exposures and processes leading to brain damage in the most immature newborns become more readily available, those who apply a systems approach to the study of neuroscience can be persuaded to study the pathogenesis of brain disorders in the very preterm newborn.
Reference Key
eleviton2015frontierssystems Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Alan eLeviton;Pierre eGressens;Olaf eWolkenhauer;Olaf eDammann
Journal Vacuum
Year 2015
DOI
10.3389/fnsys.2015.00058
URL
http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00058/full
Keywords
inflammation systems biology epigenetic prematurity brain neuropsychiatry biological psychiatry

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