notch, wnt, and hedgehog pathways in rhabdomyosarcoma: from single pathways to an integrated network

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ID: 200517
2012
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Abstract
Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children. Regarding histopathological criteria, RMS can be divided into 2 main subtypes: embryonal and alveolar. These subtypes differ considerably in their clinical phenotype and molecular features. Abnormal regulation or mutation of signalling pathways that regulate normal embryonic development such as Notch, Hedgehog, and Wnt is a recurrent feature in tumorigenesis. Herein, the general features of each of the three pathways, their implication in cancer and particularly in RMS are reviewed. Finally, the cross-talking among these three pathways and the possibility of better understanding of the horizontal communication among them, leading to the development of more potent therapeutic approaches, are discussed.
Reference Key
roma2012sarcomanotch, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Josep Roma;Anna Almazán-Moga;Josep Sánchez de Toledo;Soledad Gallego
Journal the journal of physiology
Year 2012
DOI
10.1155/2012/695603
URL
http://dx.doi.org/10.1155/2012/695603
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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