the association between myocardial iron load and ventricular repolarization parameters in asymptomatic beta-thalassemia patients
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2012
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Abstract
Previous studies have demonstrated impaired ventricular repolarization in patients with β-TM. However, the effect of iron overload with cardiac T2* magnetic resonance imaging (MRI) on cardiac repolarization remains unclear yet. We aimed to examine relationship between repolarization parameters and iron loading using cardiac T2* MRI in asymptomatic β-TM patients. Twenty-two β-TM patients and 22 age- and gender-matched healthy controls were enrolled to the study. From the 12-lead surface electrocardiography, regional and transmyocardial repolarization parameters were evaluated manually by two experienced cardiologists. All patients were also undergone MRI for cardiac T2* evaluation. Cardiac T2* score <20 msec was considered as iron overload status. Of the QT parameters, QT duration, corrected QT interval, and QT peak duration were significantly longer in the β-TM group compared to the healthy controls. Tp−Te and Tp−Te dispersions were also significantly prolonged in β-TM group compared to healthy controls. (Tp-Te)/QT was similar between groups. There was no correlation between repolarization parameters and cardiac T2* MRI values. In conclusion, although repolarization parameters were prolonged in asymptomatic β-TM patients compared with control, we could not find any relation between ECG findings and cardiac iron load.
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| Reference Key |
kayrak2012advancesthe
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|---|---|
| Authors | ;Mehmet Kayrak;Kadir Acar;Enes Elvin Gul;Orhan Özbek;Turyan Abdulhalikov;Osman Sonmez;Hajrudin Alibaşiç |
| Journal | the european journal of general practice |
| Year | 2012 |
| DOI |
10.1155/2012/170510
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| URL | |
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