apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus

Clicks: 174
ID: 200083
2016
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Abstract
The prevalence of diabetes mellitus (DM) is increasing secondary to increased consumption of food and decreased physical activity worldwide. Hyperglycaemia, insulin resistance and hypertrophy of pancreatic beta cells occur in the early phase of diabetes. However, with the progression of diabetes, dysfunction and loss of beta cells occur in both types 1 and 2 DM. Programmed cell death also named apoptosis is found to be associated with diabetes, and apoptosis of beta cells might be the main mechanism of relative insulin deficiency in DM. Autophagic cell death and apoptosis are not entirely distinct programmed cell death mechanisms and share many of the regulator proteins. These processes can occur in both physiologic and pathologic conditions including DM. Besides these two important pathways, endoplasmic reticulum (ER) also acts as a cell sensor to monitor and maintain cellular homeostasis. ER stress has been found to be associated with autophagy and apoptosis. This review was aimed to describe the interactions between apoptosis, autophagy and ER stress pathways in DM.
Reference Key
demirtas2016indianapoptosis, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Levent Demirtas;Aydin Guclu;Fatih Mehmet Erdur;Emin Murat Akbas;Adalet Ozcicek;Didem Onk;Kultigin Turkmen
Journal international journal of radiation biology
Year 2016
DOI
10.4103/0971-5916.200887
URL
http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2016;volume=144;issue=4;spage=515;epage=524;aulast=Demirtas
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