study on the expression of pparγ and aqp7 in 3t3-l1 adipocyte differentiation and the promoting effect of emodin
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ID: 199973
2016
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Abstract
Objective: To study the expression of PPARγ and AQP7 in 3T3-L1 adipocyte differentiation
and the promoting effect of emodin. Methods: In the process of adipocyte differentiation
induced by traditional adipocyte differentiation inducer, different concentration of emodin
was added for co-incubation, and the changes in the expression of adipose differentiationrelated marker genes FAS, AP2, GR, LPL and Pref-1 as well as the PPARγ and AQP7 protein
expression were detected. Results: The study confirmed that during 3T3-L1 adipocyte
differentiation process, differentiation marker proteins FAS, AP2, GR, LPL and Pref-1
expression significantly increased, AQP7 and PPARγ expression increased, and emodin had
dose-dependent promoting effect on cell differentiation. Conclusion: emodin has promoting
effect on the process of 3T3-L1 adipocyte differentiation, and this process may be related to
PPARγ and AQP7 expression regulated by it.
| Reference Key |
xiao-su2016journalstudy
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|---|---|
| Authors | ;Bai Xiao-Su;Liu Zhi-Ming;Li Zhi-Sen;Guo Dong |
| Journal | journal of communications |
| Year | 2016 |
| DOI |
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