selective preservation of anterior pituitary functions in patients with sheehan′s syndrome

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ID: 199692
2011
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Abstract
Background: Sheehan′s syndrome manifests as hypopituitarism following a child birth usually preceded by postpartum hemorrhage. The symptoms range from vague feelings of ill health to symptoms of a full blown panhypopituitarism. A large series of such patients is not described in the literature. Materials and Methods: We present the details of ten women with partial Sheehan′s syndrome. They presented with post-partum hemorrhage and lactation failure. Results: After delivery, seven out of ten patients had regular menstrual cycles indicating preservation of gonadotroph function. Lactotroph, thyrotroph, and somatotroph failure were present in all and corticotrophs preservation was documented in four out of ten patients. The hypophysial magnetic resonance imaging (MRI) confirmed empty sella in all. Conclusion: lactotroph, somatotroph and thyrotroph failure are common in patients with Sheehan′s syndrome. In addition to known preservation of gonadotroph axis, corticotroph axis may be preserved in some of these patients arguing against the universal treatment of these patients with glucocorticoids.
Reference Key
laway2011indianselective Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Bashir Ahmad Laway;Shahnaz Ahmad Mir;Tariq Gojwari;Tariq Rashid Shah;Abdul Hamid Zargar
Journal journal of physical chemistry a
Year 2011
DOI
10.4103/2230-8210.84874
URL
http://www.ijem.in/article.asp?issn=2230-8210;year=2011;volume=15;issue=7;spage=238;epage=241;aulast=Laway
Keywords
postpartum hemorrhage Gastroenterology clinical endocrinologydiseases of the digestive system

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