serine protease autotransporters of enterobacteriaceae (spates): biogenesis and function

Clicks: 333
ID: 199611
2010
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Abstract
Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) constitute a large family of proteases secreted by Escherichia coli and Shigella. SPATEs exhibit two distinct proteolytic activities. First, a C-terminal catalytic site triggers an intra-molecular cleavage that releases the N-terminal portion of these proteins in the extracellular medium. Second, the secreted N-terminal domains of SPATEs are themselves proteases; each contains a canonical serine-protease catalytic site. Some of these secreted proteases are toxins, eliciting various effects on mammalian cells. Here, we discuss the biogenesis of SPATEs and their function as toxins.
Reference Key
dautin2010toxinsserine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nathalie Dautin
Journal matec web of conferences
Year 2010
DOI
10.3390/toxins2061179
URL
http://www.mdpi.com/2072-6651/2/6/1179/
Keywords
siga pet espc vat

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