is it time for quadruple therapy to be first line?
Clicks: 76
ID: 199155
2003
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Abstract
The most commonly used regimen for Helicobacter pylori therapy at
present is twice-daily proton pump inhibitor (PPI)-based triple therapy.
Bismuth-based therapy is the next most common treatment used
by gastroenterologists. When a PPI is combined with bismuth-based
triple therapy (quadruple therapy), eradication rates are increased as
compared with the triple therapy alone. Three separate randomized
trials from three continents that compare quadruple therapy and PPIbased
triple therapy revealed remarkably similar results. Eradication
rates with PPI-based triple therapy and quadruple therapy were not
significantly different. The eradication rates with quadruple therapy
were 3% to 6% higher than PPI triple therapy, indicating that
quadruple therapy should be no less effective than PPI triple therapy.
Furthermore, these two therapies had similar rates of compliance and
adverse events.
| Reference Key |
laine2003canadianis
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|---|---|
| Authors | ;Loren Laine |
| Journal | indian journal of pharmacology |
| Year | 2003 |
| DOI |
10.1155/2003/303528
|
| URL | |
| Keywords |
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