assessment of serum lipid metabolism index and cytokine levels in patients with type 2 diabetes mellitus complicated by coronary heart disease after telmisartan combined with lipid-lowering drug treatment
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2017
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Abstract
Objective: To study the effect of telmisartan combined with lipid-lowering drug therapy on
serum lipid metabolism index and cytokine levels in patients with type 2 diabetes mellitus
complicated by coronary heart disease. Methods: A total of 106 patients with type 2 diabetes
mellitus complicated by coronary heart disease who were treated in our hospital between
September 2013 and October 2016 were collected and then divided into the control group (n=55)
who received conventional treatment + lipid-lowering drug treatment and the observation group
(n=51) who received conventional treatment + lipid-lowering drug + telmisartan treatment
after the therapies were reviewed. Before and after treatment, serum levels of lipid metabolism
indexes, inflammatory mediators and oxidative stress indexes were compared between
two groups of patients. Results: Before treatment, the differences in serum levels of lipid
metabolism indexes, inflammatory mediators and oxidative stress indexes were not statistically
significant between two groups of patients. After treatment, serum TG and LDL-C levels in
observation group were lower than those in control group while HDL-C level was higher than
that in control group; serum inflammatory mediators IL-6, IL-8, HMGB1 and TNF-α levels
were lower than those in control group; serum oxidative stress indexes MDA and ROS levels
were lower than those in control group while GSH-Px level was higher than that in control
group. Conclusion: Telmisartan combined with lipid-lowering drug therapy can effectively
optimize the lipid metabolism and reduce the systemic inflammatory response and oxidative
stress response in patients with type 2 diabetes mellitus complicated by coronary heart disease.
| Reference Key |
wang2017journalassessment
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| Authors | ;Xin Wang |
| Journal | journal of communications |
| Year | 2017 |
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