top-down mechanisms of anesthetic-induced unconsciousness

Clicks: 237
ID: 197914
2014
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Abstract
The question of how structurally and pharmacologically diverse general anesthetics disrupt consciousness has persisted since the 19th century. There has traditionally been a significant focus on bottom-up mechanisms of anesthetic action, in terms of sensory processing, arousal systems and structural scales. However, recent evidence suggests that the neural mechanisms of anesthetic-induced unconsciousness may involve a top-down process, which parallels current perspectives on the neurobiology of conscious experience itself. This article considers various arguments for top-down mechanisms of anesthetic-induced unconsciousness, with a focus on sensory processing and sleep-wake networks. Furthermore, recent theoretical work is discussed to highlight the possibility that top-down explanations may be causally sufficient, even assuming critical bottom-up events.
Reference Key
mashour2014frontierstop-down Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;George A. Mashour
Journal Vacuum
Year 2014
DOI
10.3389/fnsys.2014.00115
URL
http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00115/full
Keywords
sleep anesthesia consciousness general inhalation neuropsychiatry biological psychiatry

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