neuronal toxicity of biopolymer-template synthesized zno nanoparticles
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ID: 197420
2013
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Abstract
Objective(s): A simple and "green " method was developed for preparing zinc oxide nanoparticles (ZnO-NPs) in aqueous starch solutions. Starch was used as a stabilizer to control of the mobility of zinc cations and then control growth of ZnO-NPs prepared via a sol-gel method. Because of the special structure of the starch, it permits termination of the particle growth. Materials and Methods: The dried gel was calcined at different temperatures of 400, 500, 600, and 700 °C. The prepared ZnO-NPs were characterized by different techniques such as X-ray diffraction analysis (XRD), transmittance electron microscopy (TEM), and UV-Vis absorption. Results: The XRD results displayed hexagonal (wurtzite) crystalline structure for prepared ZnO nanoparticles with mean sizes below than 50 nm. In vitro cytotoxicity studies on neuro2A cells showed a dose dependent toxicity with non-toxic effect of concentration below 6 μg/mL. Discussion: The results showed that starch is an eco-friendly material that can be used as a stabilizing agent in the sol-gel technique for preparing of ZnO-NPs in a large scale.
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kargar2013nanomedicineneuronal
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| Authors | ;Hadi Kargar;Hasan Ali Hosseini;Zahra Sabouri;Reza Kazemi Oskuee;Majid Darroudi |
| Journal | Journal of visualized experiments : JoVE |
| Year | 2013 |
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