executive dysfunction in parkinson's disease and timing deficits

Clicks: 278
ID: 197096
2013
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Abstract
Patients with Parkinson’s disease (PD) have deficits in perceptual timing, or the perception and estimation of time. PD patients can also have cognitive symptoms, including deficits in executive functions such as working memory, planning, and visuospatial attention. Here, we discuss how PD-related cognitive symptoms contribute to timing deficits. Timing is influenced by signaling of the neurotransmitter dopamine in the striatum. Timing also involves the frontal cortex, which is dysfunctional in PD. Frontal cortex impairments in PD may influence memory subsystems as well as decision processes during timing tasks. These data suggest that timing may be a type of executive function. As such, timing can be used to study the neural circuitry of cognitive symptoms of PD as they can be studied in animal models. Performance of timing tasks also maybe a useful clinical biomarker of frontal as well as striatal dysfunction in PD.
Reference Key
parker2013frontiersexecutive Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Krystal L Parker;Dronacharya eLamichhane;Marcelo S Caetano;Nandakumar S Narayanan;Nandakumar S Narayanan
Journal drug research
Year 2013
DOI
10.3389/fnint.2013.00075
URL
http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00075/full
Keywords
cognitive impairment parkinson’s disease executive function interval timing diseases of the nervous system neuropsychiatryneurology biological psychiatry

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