capillary deposition of complement c4d and c3d in chinese renal allograft biopsies
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2015
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Abstract
Background. C3d is a product of both the classic and the alternative complement cascades; however, few studies have addressed the role of C3d in renal biopsies and its relationship with long-term graft survival rate is not very clear. Methods. 94 patients with biopsy-proven acute rejection episodes were included in the study. We investigated the associations between histological findings, clinical examinations, and outcome. Results. The overall prevalence for C4dPTC and C3dPTC was 42.6% and 29.8%. There was a significant association between C3dPTC and C4dPTC (P<0.001). C3dPTC and C4dPTC were related with histological types (P=0.024 and P<0.001, resp.). The long-term survival rate for C4dPTC positive transplants was lower than that of C4dPTC negative transplants, but it was not statistic significant in our study (P=0.150). The survival rate of C3dPTC positive group was much lower than the negative group (P=0.014). Patients with double positives for C4dPTC and C3dPTC exhibited the lowest survival rate significantly different from those of the C3dPTC only and C4dPTC only groups (P=0.01 and P=0.0037). Conclusions. This longitudinal cohort study has demonstrated that C3d deposition in the PTC was closely related to renal dysfunction and pathological changes.
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| Reference Key |
lv2015diseasecapillary
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|---|---|
| Authors | ;Rong Lv;Wei Zhang;Fei Han;Guangjun Liu;Wenqing Xie;Jianghua Chen |
| Journal | international journal of psychology : journal international de psychologie |
| Year | 2015 |
| DOI |
10.1155/2015/397613
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| URL | |
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