new techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis

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ID: 196505
2016
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Abstract
Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing. To meet these emerging demands on biopharmaceutical analysis, this paper summarizes several new techniques of on-line biological sample processing: solid phase extraction, solid phase micro-extraction, column switching, limited intake filler, molecularly imprinted solid phase extraction, tubular column, and micro-dialysis. We describe new developments, principles, and characteristics of these techniques, and the application of liquid chromatography–mass spectrometry (LC–MS) in biopharmaceutical analysis with these new techniques in on-line biological sample processing.
Reference Key
peng2016actanew Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jie Peng;Fang Tang;Rui Zhou;Xiang Xie;Sanwang Li;Feifan Xie;Peng Yu;Lingli Mu
Journal energy policy
Year 2016
DOI
10.1016/j.apsb.2016.05.016
URL
http://www.sciencedirect.com/science/article/pii/S2211383516300697
Keywords
restricted access material pharmacology column

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