estudo clínico-eletrencefalográfico longitudinal em pacientes epilépticos tratados com ro 5-4023 longitudinal clinical and electroencephalographieal studies in epileptic patients treated with ro 5-4023
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1970
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Abstract
Estudaram-se as modificações do quadro clínico e do quadro eletrencefalográfico em 22 pacientes com manifestações epilépticas diárias (5 com ausências típicas, 3 com crises psicomotoras, 5 com ausências mioclônicas, 1 com mioclonias de ação e 8 com síndrome de Lennox), tratados com 7-nitro-5-(2clorofenil)-3H-1,4 benzodiazepina 2 (1H)-one ou Ro 5-4023. Vinte pacientes tinham sido submetidos a terapêuticas anticonvulsivantes usuais sem resultados apreciáveis. Com o uso de Ro 5-4023 as crises foram controladas desde o primeiro dia em 14 pacientes. Em mais 6 doentes houve redução rápida e significativa da intensidade e da freqüência das crises. Destes, um não mais apresentou manifestações a partir da segunda semana de tratamento. Recidivas parciais ocorreram em 8 pacientes. Destaca-se o amplo campo de ação da droga, que age nas epilepsias generalizadas (ausências típicas e ausências mioclônicas), em epilepsias parciais, particularmente crises psicomotoras da infância com ponta-ondas lentas, nas encefalopatias epilépticas graves da infância, de tipo Lennox, e também em síndrome epiléptico degenerativo. Os efeitos colaterais, presentes em 11 pacientes, foram passageiros em 9. Precipitação de crises generalizadas tônico-clônicas ocorreu em dois pacientes; contudo há indícios que esse fenômeno é mais freqüente com outros derivados benzodiazepínicos. As modificações do EEG incluiram desaparecimento ou diminuição das descargas bilaterais e difusas, espontâneas e/ou desencadeadas pela estimulação luminosa intermitente, aparecimento de ritmos rápidos e difusos, persistência ou aparecimento de anormalidades focais lentas ou de tipo irritativo.
Twenty two epileptic patients, with daily seizures (5 had typical absences, 3 had psychomotor seizures, 5 had myoclonic absences, one had intentional myoclonia and 8 had Lennox syndrome) were treated with 7-nitro-5-(2chlorophenyl)-3H-1,4 benzodiazepine-2(1H)-one or Ro 5-4023. Twenty of these patients had received previous treatment with other anticonvulsivant drugs with no satisfactory results. A clinical and electroencephalographical longitudinal study was made on these patients. With the use of Ro 5-4023 the seizures were completely controlled since the first day in 14 patients; in 6 there was a rapid and significant decrease in frequency and intensity of seizures; in one, out of these 6, seizures disappeared during the second week of treatment. Recurrence of seizures were observed in 8 patients. The drug is effective in a large spectrum of generalized seizures (typical absences, myoclonic absences); partial seizures, in particular the psychomotor seizures of infancy with slow spike-waves; the severe epileptic encephalopathy of infancy, Lennox type; and the degenerative epileptic syndrome. Side effects due to the drug were present in 11 patients, being of short duration in 9. In two patients there was precipitation of generalized tonic-clonic seizures; anyhow it seems that the occurrence of this complication is more frequent when one uses other types of benzodiazepines. Electroencephadographic studies showed improvement of the previous abnormalities; there was disappearance or decrease of bilateral diffuse discharges, when spontaneous or provoked by intermitent light stimuli, onset of diffuse, fast rhythm, persistance or onset of slow focal abnormalities or irritative type of discharges.
Twenty two epileptic patients, with daily seizures (5 had typical absences, 3 had psychomotor seizures, 5 had myoclonic absences, one had intentional myoclonia and 8 had Lennox syndrome) were treated with 7-nitro-5-(2chlorophenyl)-3H-1,4 benzodiazepine-2(1H)-one or Ro 5-4023. Twenty of these patients had received previous treatment with other anticonvulsivant drugs with no satisfactory results. A clinical and electroencephalographical longitudinal study was made on these patients. With the use of Ro 5-4023 the seizures were completely controlled since the first day in 14 patients; in 6 there was a rapid and significant decrease in frequency and intensity of seizures; in one, out of these 6, seizures disappeared during the second week of treatment. Recurrence of seizures were observed in 8 patients. The drug is effective in a large spectrum of generalized seizures (typical absences, myoclonic absences); partial seizures, in particular the psychomotor seizures of infancy with slow spike-waves; the severe epileptic encephalopathy of infancy, Lennox type; and the degenerative epileptic syndrome. Side effects due to the drug were present in 11 patients, being of short duration in 9. In two patients there was precipitation of generalized tonic-clonic seizures; anyhow it seems that the occurrence of this complication is more frequent when one uses other types of benzodiazepines. Electroencephadographic studies showed improvement of the previous abnormalities; there was disappearance or decrease of bilateral diffuse discharges, when spontaneous or provoked by intermitent light stimuli, onset of diffuse, fast rhythm, persistance or onset of slow focal abnormalities or irritative type of discharges.
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| Authors | ;Michel P. Lison;Laertel F. Fassoni |
| Journal | communications in computer and information science |
| Year | 1970 |
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