loss of specificity in basal ganglia related movement disorders
Clicks: 333
ID: 196287
2011
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Popular Article
30.0
/100
333 views
41 readers
AI Quality Assessment
Not analyzed
Readership in this journal
PopularRanked #19 of 133 articles by views in Vacuum
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 133 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
The basal ganglia (BG) are a group of interconnected nuclei which play a pivotal partin limbic, associative and motor functions. This role is mirrored by the wide range ofmotor and behavioral abnormalities directly resulting from dysfunctions of the BG.Studies of normal behavior have found that BG neurons tend to phasically modulatetheir activity in relation to different behavioral events. In the normal BG, thismodulation is highly specific, with each neuron related only to a small subset ofbehavioral events depending on specific combinations of movement parameters andcontext.. In many pathological conditions involving BG dysfunction and motorabnormalities, this neuronal specificity is lost. Loss of specificity (LOS) manifests inneuronal encoding of a larger spectrum of events and consequently a large overlap ofmovement-related activation patterns between different neurons. We review theexisting evidence for LOS in BG-related movement disorders, the possible neuralmechanisms underlying LOS, its effects on frequently used measures of neuronalactivity and its relation to theoretical models of the BG. The prevalence of LOS in amany BG-related disorders suggests that neuronal specificity may represent a keyfeature of normal information processing in the BG system. Thus, the concept ofneuronal specificity may underlie a unifying conceptual framework for the BG role innormal and abnormal motor control.
| Reference Key |
ebronfeld2011frontiersloss
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Maya eBronfeld;Izhar eBar‐Gad;Izhar eBar‐Gad |
| Journal | Vacuum |
| Year | 2011 |
| DOI |
10.3389/fnsys.2011.00038
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.