shigella iron acquisition systems and their regulation

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ID: 195868
2016
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Abstract
Survival of Shigella within the host is strictly dependent on the ability of the pathogen to acquire essential nutrients, such as iron. As an innate immune defense against invading pathogens, the level of bio-available iron within the human host is maintained at exceeding low levels, by sequestration of the element within heme and other host iron-binding compounds. In response to sequestration mediated iron limitation, Shigella produce multiple iron-uptake systems that each function to facilitate the utilization of a specific host-associated source of nutrient iron. As a mechanism to balance the essential need for iron and the toxicity of the element when in excess, the production of bacterial iron acquisition systems is tightly regulated by a variety of molecular mechanisms. This review summarizes the current state of knowledge on the iron-uptake systems produced by Shigella species, their distribution within the genus, and the molecular mechanisms that regulate their production.
Reference Key
ewei2016frontiersshigella Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yahan eWei;Erin R. Murphy
Journal electronic physician
Year 2016
DOI
10.3389/fcimb.2016.00018
URL
http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00018/full
Keywords
virulence regulation pathogenesis iron acquisitionmicrobiology

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