pathobiology of anaplastic large cell lymphoma

Clicks: 140
ID: 195006
2010
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Abstract
The authors revise the concept of anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated with special reference to the cytological spectrum that is indeed characteristic of the tumor. The phenotype is reported in detail: the expression of the ALK protein as well as the chromosomal abnormalities is discussed with their potential pathogenetic implications. The clinical features of ALCL are presented by underlining the difference in terms of response to therapy and survival between the ALK-positive and ALK-negative forms. Finally, the biological rationale for potential innovative targeted therapies is presented.
Reference Key
piccaluga2010advancespathobiology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Pier Paolo Piccaluga;Anna Gazzola;Claudia Mannu;Claudio Agostinelli;Francesco Bacci;Elena Sabattini;Carlo Sagramoso;Roberto Piva;Fernando Roncolato;Giorgio Inghirami;Stefano A. Pileri
Journal the european journal of general practice
Year 2010
DOI
10.1155/2010/345053
URL
http://dx.doi.org/10.1155/2010/345053
Keywords
Diseases of the blood and blood-forming organs

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