the clinical significance of β-arrestin 2 expression in the serum of non-small cell lung cancer patients
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2011
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Abstract
Background and objective Non-small cell lung cancer (NSCLC) with high morbidity and mortality is the most common types of lung cancer. beta-arrestin 2 is a kind of soluble protein regulating signal transduction mediated by G protein coupling receptor. The aim of this research is to evaluate the clinical significance of β-arrestin 2 expression in the serum of NSCLC patients. Methods The clinical and follow-up data of 20 healthy candidates and 67 patients diagnosed with NSCLC in Sun Yat-sen University Cancer Center from January 2005 to December 2006 was retrospectively analyzed. ELISA was applied to detect the expression of beta-arrestin 2. Results The serum level of β-arrestin 2 in NSCLC patients were all significally lower than those in healthy controls (P<0.001, P<0.001, P<0.001). The serum level of β-arrestin 2 in stage I NSCLC patients were higher than those in stage III as well as in stage IV (P<0.001, P<0.001). No statistical difference of β-arrestin 2’ serum level was found between with stage III and stage IV patients (P=0.273). Univariate prognostic factor analyzed by Kaplan-Meier method indicated patients’ prognosis with high serum level of β-arrestin 2 was better than patients with low and middle (P<0.001, P<0.001). The serum level of β-arrestin 2 and the stage of NSCLC signally affected prognosis in COX regression model (P=0.003, P=0.004). Conclusion The serum level of β-arrestin 2 had significant difffrence between NSCLC patients and healthy controls, likewise between the early and advanced NSCLC patients. The serum level of β-arrestin 2 affected NSCLC patients’ prognosis.
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wu2011chinesethe
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| Authors | ;Zhengqing WU;Wenxia TONG;Zihui TAN;Siyu WANG;Peng LIN |
| Journal | proceedings of the 10th acm multimedia systems conference, mmsys 2019 |
| Year | 2011 |
| DOI |
10.3779/j.issn.1009-3419.2011.06.04
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