expression and significance of il-1β and cox-2 in gingiva tissues in rat periodontitis model with different estrogen levels
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2017
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Abstract
Objective: To explore the expressions of IL-1β and COX-2 in the gingiva tissues in
rat periodontitis model with different estrogen levels, and the effect of estrogen level on
periodontitis. Methods: A total of 40 female Wistar rats were randomized into 4 groups, i.e.
normal control group (n=10), periodontitis group (n=10), castraction periodontitis group (n=10),
and estrogen therapy group (n=10). RT-PCR was used to detect the expressions of IL-1β
and COX-2 in the gingiva tissues in each group. Results: The expression intensity of IL-1β
and COX-2 in the estrogen therapy group was significantly lower than that in the castraction
periodontitis group (P<0.05). Conclusions: Estrogen can significantly down regulate the
expressions of IL-1β and COX-2 in order to alleviate the symptoms of periodontitis.
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| Reference Key |
ku2017journalexpression
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|---|---|
| Authors | ;Li-Bo Ku;Guo-Quan Xu;Hui Wang;Zhi-Hua Zhao;Shi-Yu Ding;Li Ma |
| Journal | journal of communications |
| Year | 2017 |
| DOI |
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