ifn-lambda: a new inducer of local immunity against cancer and infections

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ID: 193829
2016
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Abstract
IFN-λ is the newly established type III IFN with unique immuno-modulatory functions. In contrast to the IFN- family and to some extent IFN-, IFN-λ acts in specific areas of the body to activate resident immune cells and induce local immunity, and is instrumental in preventing infections and keeping transformed cells under control. Mucosal areas of the lung and gastrointestinal tract are now under scrutiny in the elucidation of the immune mechanisms triggered by IFN-λ. New evidence also indicates the crucial role of IFN-λ in promoting viral protection and inducing innate immunity against solid cancers. Based on its unique biological activities among the members of the IFN system, new immunotherapeutic approaches centered around IFN-λ are now emerging for the treatment of cancer, infection, and autoimmune diseases. In the present review, we highlight the recent advances involving IFN-λ immuno-modulatory functions. We also discuss the potential of utilizing IFN-λ as a therapeutic agent.
Reference Key
lasfar2016frontiersifn-lambda: Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ahmed Lasfar;Ahmed Lasfar;Andrew Zloza;Andrew de la Torre;Andrew de la Torre;Karine A Cohen Solal
Journal sudebno-meditsinskaia ekspertiza
Year 2016
DOI
10.3389/fimmu.2016.00598
URL
http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00598/full
Keywords
inflammation mucosal immunity nk cells allergy

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