synthesis and bacteriostatic activities of bis(thiourea) derivatives with variable chain length
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ID: 193538
2016
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Abstract
A series of 1,4-bis(decoxyphenyl)carbamothioyl-terephthalamide derivatives was successfully synthesised by reaction of benzene-1,4-dicarbonyl isothiocyanate intermediates with long alkyl chain. The alkylation was performed via Williamson etherification of 4-acetamidophenol with bromoalkanes. The synthesised bis(thiourea) derivatives differed in the chain length, CnH2n+1, where n=10, 12, and 14. The structures of all compounds were characterised by elemental CHN analysis, IR, 1H, and 13C NMR spectroscopies. Bacteriostatic activities of bis(thiourea derivatives which consisted of two folds of N-H, C=O, and C=S and long alkyl chain substituents were carried out against Gram-negative bacteria (Escherichia coli, ATCC 25922) via turbidimetric kinetic method. Bis(thiourea) derivatives with n=10 and n=12 displayed excellent activity against E. coli with MIC of 135 µg/mL and 145 µg/mL, respectively, while bis(thiourea) derivatives with n=14 acted as cutoff point with no antibacterial properties. Similar trend was observed in binding affinity to the active site of enoyl ACP reductase (FabI), which demonstrated binding free energy of -5.3 Kcal/mol and -4.9 and -4.8 Kcal/mol, respectively.
| Reference Key |
halim2016journalsynthesis
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|---|---|
| Authors | ;Ainaa Nadiah Abd Halim;Zainab Ngaini |
| Journal | british journal of psychology (london, england : 1953) |
| Year | 2016 |
| DOI |
10.1155/2016/2739832
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