cytotoxic proteins and therapeutic targets in severe cutaneous adverse reactions
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ID: 193407
2014
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Abstract
Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are rare but life-threatening conditions induced mainly by a variety of drugs. Until now, an effective treatment for SJS/TEN still remains unavailable. Current studies have suggested that the pathobiology of drug-mediated SJS and TEN involves major histocompatibility class (MHC) I-restricted activation of cytotoxic T lymphocytes (CTLs) response. This CTLs response requires several cytotoxic signals or mediators, including granulysin, perforin/granzyme B, and Fas/Fas ligand, to trigger extensive keratinocyte death. In this article, we will discuss the cytotoxic mechanisms of severe cutaneous adverse reactions and their potential applications on therapeutics for this disease.
| Reference Key |
su2014toxinscytotoxic
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|---|---|
| Authors | ;Shih-Chi Su;Wen-Hung Chung |
| Journal | matec web of conferences |
| Year | 2014 |
| DOI |
10.3390/toxins6010194
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| URL | |
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