a model study of epothilone synthesis: an alternative synthetic approach to the c1c7 fragment
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ID: 192398
2002
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Abstract
In this model study an alternative synthetic approach to the C1C7 fragment of epothilones was investigated. Starting from 4,4-dimethylcyclopentenone, a 7 step reaction sequence afforded the key intermediate 7 in 27 % overall yield. Surprisingly, the attempted deprotection of latent functionalities in 7 failed, indicating the incompatibility of the ethoxyethyl protective group with the reaction conditions employed.
| Reference Key |
saicic2002journala
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|---|---|
| Authors | ;RADOMIR N. SAICIC;RADOMIR MATOVIC;DANICA GALONIC;GOJKO LALIC |
| Journal | meditsinskaia radiologiia |
| Year | 2002 |
| DOI |
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| Keywords | Keywords not found |
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