a panel of ca19-9, ca125, and ca15-3 as the enhanced test for the differential diagnosis of the pancreatic lesion
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2017
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Abstract
Background. Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma. Studies suggest that surgery for suspected pancreatic ductal adenocarcinoma (PDAC) reveals a benign lesion in 5% to 13% of cases. The aim of our study was to assess whether routinely used biomarkers such as CA19-9, Ca125, Ca15-3, and CEA, when combined, can potentially yield an accurate test predicting pancreatic lesion etiology. Methods. We retrospectively analyzed data of 326 patients who underwent a diagnostic process due to pancreatic lesions of unknown etiology. Results. We found statistically significant differences in mean levels of all biomarkers. In logistic regression model, we applied levels CA19-9, Ca125, and Ca15-3 as variables. Two validation methods were used, namely, random data split into training and validation groups and bootstrapping. Afterward, we built ROC curve using the model that we had created, reaching AUC = 0,801. With an optimal cut-off point, it achieved specificity of 81,2% and sensitivity of 63,10%. Our proposed model has superior diagnostic accuracy to both CA19-9 (p = 0,0194) and CA125 (p = 0,0026). Conclusion. We propose a test that is superior to CA19-9 in a differential diagnosis of pancreatic lesion etiology. Although our test fails to reach exceptionally high accuracy, its feasibility and cost-effectiveness make it clinically useful.
| Reference Key |
hogendorf2017diseasea
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| Authors | ;Piotr Hogendorf;Aleksander Skulimowski;Adam Durczyński;Anna Kumor;Grażyna Poznańska;Aleksandra Oleśna;Joanna Rut;Janusz Strzelczyk |
| Journal | international journal of psychology : journal international de psychologie |
| Year | 2017 |
| DOI |
10.1155/2017/8629712
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| URL | |
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