the p-type atpase pa1429 regulates quorum-sensing systems and bacterial virulence

Clicks: 482
ID: 191635
2017
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #2 of 875 articles by views in journal of magnetic resonance (san diego, calif : 1997)

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 875 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Pseudomonas aeruginosa is becoming an increasingly prevalent pathogen, capable of causing numerous life threatening infections in immunocompromised patients. The three hierarchically arranged quorum sensing (QS) systems, namely las, rhl, and pqs play key roles in coordinating virulence expression in P. aeruginosa. However, the regulatory mechanisms of the pqs system have not been fully elucidated. To identify new genes involved in synthesis of the Pseudomonas quinolone signal (PQS), a transposon mutagenesis library was constructed. PA1429 was found to inhibit PQS biosynthesis. The PA1429 deletion mutant also exhibited increased bacterial motility, biofilm formation, and virulence in a mouse model of acute lung infection. Interestingly, it also displayed reduced tolerance to oxidative stress. Mutated pqsH in the PA1429 deletion background restored bacterial susceptibility to H2O2. In addition, our data showed that PA1429 repressed the expression of las and rhl systems. Overall, these results provide new insights into the complex regulatory networks of quorum-sensing and virulence expression in P. aeruginosa.
Reference Key
zhang2017frontiersthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yani Zhang;Jing Qin;Boren Tan;Boren Tan;Weina Kong;Gukui Chen;Chao Zhang;Haihua Liang
Journal journal of magnetic resonance (san diego, calif : 1997)
Year 2017
DOI
10.3389/fmicb.2017.02449
URL
http://journal.frontiersin.org/article/10.3389/fmicb.2017.02449/full
Keywords
virulence Pseudomonas aeruginosa mutation image analysis snp parkinson's disease antioxidant enzymes meiosis male sterility heat stress quorum sensing mycoplasma gallisepticum chicken mirnas oryza sativa transgenic secale cereale elicitor mg computational model tall fescue photosystem ii iaa shiraz al toxicity plant cell wall diseases of the nervous system neuropsychiatry biological psychiatry transcription factoragriculture (general)

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.