analysis of complement c3 gene reveals susceptibility to severe preeclampsia

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ID: 190451
2017
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Abstract
Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition. Dysregulation of the complement system has been implicated, but molecular mechanisms are incompletely understood. In this study, we determined the potential linkage of severe PE to the most central complement gene, C3. Three cohorts of Finnish patients and controls were recruited for a genetic case-control study. Participants were genotyped using Sequenom genotyping and Sanger sequencing. Initially, we studied 259 Finnish patients with severe PE and 426 controls from the Southern Finland PE and the Finnish population-based PE cohorts. We used a custom-made single nucleotide polymorphism (SNP) genotyping assay consisting of 98 SNPs in 18 genes that encode components of the complement system. Following the primary screening, C3 was selected as the candidate gene and consequently Sanger sequenced. Fourteen SNPs from C3 were also genotyped by a Sequenom panel in 960 patients with severe PE and 705 controls, including already sequenced individuals. Three of the 43 SNPs observed within C3 were associated with severe PE: rs2287845 (p = 0.038, OR = 1.158), rs366510 (p = 0.039, OR = 1.158), and rs2287848 (p = 0.041, OR = 1.155). We also discovered 16 SNP haplotypes with extreme linkage disequilibrium in the middle of the gene with a protective (p = 0.044, OR = 0.628) or a predisposing (p = 0.011, OR = 2.110) effect to severe PE depending on the allele combination. Genetic variants associated with PE are located in key domains of C3 and could thereby influence the function of C3. This is, as far as we are aware, the first candidate gene in the complement system with an association to a clinically relevant PE subphenotype, severe PE. The result highlights a potential role for the complement system in the pathogenesis of PE and may help in defining prognostic and therapeutic subgroups of preeclamptic women.
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lokki2017frontiersanalysis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;A. Inkeri Lokki;A. Inkeri Lokki;A. Inkeri Lokki;Tea Kaartokallio;Ville Holmberg;Ville Holmberg;Päivi Onkamo;Lotta L. E. Koskinen;Päivi Saavalainen;Seppo Heinonen;Eero Kajantie;Eero Kajantie;Eero Kajantie;Juha Kere;Juha Kere;Juha Kere;Katja Kivinen;Anneli Pouta;Anneli Pouta;Pia M. Villa;Pia M. Villa;Leena Hiltunen;Hannele Laivuori;Hannele Laivuori;Hannele Laivuori;Seppo Meri;Seppo Meri
Journal sudebno-meditsinskaia ekspertiza
Year 2017
DOI
10.3389/fimmu.2017.00589
URL
http://journal.frontiersin.org/article/10.3389/fimmu.2017.00589/full
Keywords
preeclampsia gene regulation complement association study allergy

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