a role for bcl-2 in notch1-dependent transcription in thymic lymphoma cells

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ID: 190449
2012
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Abstract
Notch1 is a transcription factor important for T-cell development. Notch1 is active in double negative (DN) thymocytes, while being depressed in double positive (DP) thymocytes. Synchronously, the expression of Bcl-2 becomes downregulated during the transition from DN to DP thymocytes. We previously observed that overexpression of an intracellular active Notch1 (ICN) in Bcl-2-positive 2B4 T cells leads to the transcription of Notch1-regulated genes. However, these genes were not induced in Bcl-2-negative DP PD1.6 thymic lymphoma cells overexpressing ICN. Here we show that, when Bcl-2 is simultaneously introduced into these cells, Notch-regulated genes are transcribed. Only in the presence of both Bcl-2 and ICN, PD1.6 thymic lymphoma cells become resistant to glucocorticoid (GC)-induced apoptosis. Our data suggest that Bcl-2 plays a role in modulating Notch1 function in T cells.
Reference Key
sionov2012advancesa Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ronit Vogt Sionov;Shlomit Kfir-Erenfeld;Rachel Spokoini;Eitan Yefenof
Journal the european journal of general practice
Year 2012
DOI
10.1155/2012/435241
URL
http://dx.doi.org/10.1155/2012/435241
Keywords
Diseases of the blood and blood-forming organs

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