disseminated necrotizing leukoencephalopathy complicating septic shock in an immunocompetent patient

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ID: 190179
2017
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Abstract
Disseminated necrotizing leukoencephalopathy (DNL) is characterized by multiple microscopic foci of white matter necrosis. DNL was initially thought to be exclusively associated with immunosuppression conditions but it has been recently described in immunocompetent patients in septic shock. A 90-year-old immunocompetent woman with no previous neurological impairment presented with septic shock and drowsiness that responded well to therapy with clinical improvement and a full neurological recovery. Unexpectedly deterioration with progression to coma occurred. Investigation excluded other causes and Magnetic Resonance Imaging (MRI) was consistent with the diagnosis of DNL showing bilateral multifocal white matter lesions with a nonvascular pattern with restricted diffusion. Neurological impairment persisted with progression to death. DNL is an unexpected diagnosis in an immunocompetent patient. We compared the present case to those found in the literature of DNL complicating septic shock and discuss the antemortem diagnosis based on MRI findings.
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gaspar-da-costa2017casedisseminated Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Pedro Gaspar-da-Costa;Sofia Reimão;Sandra Braz;João Meneses Santos;Rui M. M. Victorino
Journal trendy ekonomiky a managementu
Year 2017
DOI
10.1155/2017/1092537
URL
http://dx.doi.org/10.1155/2017/1092537
Keywords
critical care first aid intensive care medical emergencies

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