ethanolamine and phosphatidylethanolamine: partners in health and disease
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ID: 190109
2017
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Abstract
Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian cells. PE comprises about 15–25% of the total lipid in mammalian cells; it is enriched in the inner leaflet of membranes, and it is especially abundant in the inner mitochondrial membrane. PE has quite remarkable activities: it is a lipid chaperone that assists in the folding of certain membrane proteins, it is required for the activity of several of the respiratory complexes, and it plays a key role in the initiation of autophagy. In this review, we focus on PE’s roles in lipid-induced stress in the endoplasmic reticulum (ER), Parkinson’s disease (PD), ferroptosis, and cancer.
| Reference Key |
patel2017oxidativeethanolamine
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|---|---|
| Authors | ;Dhaval Patel;Stephan N. Witt |
| Journal | journal of aoac international |
| Year | 2017 |
| DOI |
10.1155/2017/4829180
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| URL | |
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