drug resistance analysis by next generation sequencing in leishmania

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ID: 189536
2015
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Abstract
The use of next generation sequencing has the power to expedite the identification of drug resistance determinants and biomarkers and was applied successfully to drug resistance studies in Leishmania. This allowed the identification of modulation in gene expression, gene dosage alterations, changes in chromosome copy numbers and single nucleotide polymorphisms that correlated with resistance in Leishmania strains derived from the laboratory and from the field. An impressive heterogeneity at the population level was also observed, individual clones within populations often differing in both genotypes and phenotypes, hence complicating the elucidation of resistance mechanisms. This review summarizes the most recent highlights that whole genome sequencing brought to our understanding of Leishmania drug resistance and likely new directions.
Reference Key
leprohon2015internationaldrug Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Philippe Leprohon;Christopher Fernandez-Prada;Élodie Gazanion;Rubens Monte-Neto;Marc Ouellette
Journal deutsche zeitschrift fur philosophie
Year 2015
DOI
10.1016/j.ijpddr.2014.09.005
URL
http://www.sciencedirect.com/science/article/pii/S2211320714000281
Keywords
Drug resistance next generation sequencing genome single nucleotide polymorphisms aneuploidy leishmania

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