Anti-obesity efficacy of the selected high altitude Himalayan herbs: in vitro studies.

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ID: 189365
2020
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Abstract
Obesity is a serious health problem for all age groups and it also promotes Type 2 diabetes, cardiovascular diseases, cancer and hypertension. Herbs are used for the weight reduction from ancient times, therefore, 12 herbs viz. and were selected as per literature. roots showed the highest extraction rate (39.5%), while leaf showed lowest extraction rate (1.25%) as compared to other herbs. As well, leaf extract (396.52 mg GAE/g), root extract (181.5 mg QE/g), and leaf extract (79.19%) showed significantly higher Total Phenolic Content, Total Flavonoid Content and antioxidant activity, respectively. Furthermore, lipase and amylase inhibition activity and IC50 value of herb extract were higher in root extract (75.75%, 75.41% and 62.47, 61.37, respectively). leaf extract showed a significantly higher glucose level, percentage of glucose movement (1.446 mg/dL and 63.85%) and (0.938 mg/dL and 76.55%). Based upon these experiments, 5 herbs were selected and different formulations were prepared and out of these, F3 herb formulation showed higher lipase and amylase inhibition activity (81.75% and 70.66%) and therefore, F3 herbal formulation was selected for treatment of obesity.
Reference Key
kumar2020antiobesityjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kumar, Mukul;Guleria, Samriti;Chawla, Prince;Khan, Azhar;Modi, V K;Kumar, Naveen;Kaushik, Ravinder;
Journal Journal of food science and technology
Year 2020
DOI
10.1007/s13197-020-04341-5
URL
Keywords
obesity lipase formulation glucose amylase herbs

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