development and physical evaluation of maytenus ilicifolia effervescent granules using factorial design
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ID: 188945
2014
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Abstract
The medicinal plant Maytenus ilicifolia is a commonly used phytomedicine for the treatment of gastritis. The high dose required and low density of these extracts make necessary a daily intake of several capsules, hindering adherence to the medication. The purpose of this work was to develop a suitable dosage form for the administration of Maytenus ilicifolia using effervescent granules. A 23 factorial design was used to study the physical characteristics of the granules (particle size distribution, repose angle, Carr index, scanning electron microscopy and disintegration time). Moisture stability was also determined. According to the experimental design, granule size is the most important factor in determining the flow characteristics of effervescent granules. In turn, the disintegration time is controlled by the content of sodium bicarbonate present in the effervescent mixture as well as the granule size. The stability of formulations when exposed to moisture is strongly influenced by the percentage of effervescent mixture present in the vegetal granules. Precautions in handling and storage should be taken to ensure the stability of these preparations. The effervescent granules produced from Maytenus ilicifolia met the pharmacopoeial quality parameters, with appropriate mechanical and physical characteristics and proved to be a promising vehicle for plant extracts.
| Reference Key |
cunha-filho2014braziliandevelopment
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|---|---|
| Authors | ;Marcilio Sérgio Soares da Cunha-Filho;Pricila Castilho Gustmann;Felipe Sanches Garcia;Eliana Martins Lima;Lívia Cristina Lira de Sá-Barreto |
| Journal | electronic engineering times |
| Year | 2014 |
| DOI |
10.1590/S1984-82502014000200002
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| URL | |
| Keywords | Keywords not found |
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