the effect of prangos ferulacea l on the haematologic indices of diabetic rats
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ID: 188559
2015
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Abstract
Background
& Objective:
Diabetes mellitus is a heterogenic metabolic disease in which hyperglycemia
leads to glycosylation of RBC membrane and damage of bone marrow stem cells. Because
of high flavonoid content of Prangos Ferulacea lindl, the effects of its aqueous-
alcoholic extracts on hematologic incidences of diabetic male rats have been
studied.
Materials
& Methods:
In this study, 60 adult male rats of Wistar race, (body weight 200±20 g) were
divided randomly into 6 groups of 10 members. The control group did not receive
any medication or herbal extract, while the blank group received the solvent
alone. Test group 1 was administered by 300 mg/kg.bw prangos Ferulacea extract
as gavages. Test group 2 received only 60 mg/kg. bw intraperitoneal
strptozotocin. Test group 3 and 4 were administered by 300 mg/kg.bw and 600
mg/kg.bw Prangos Ferulacea extract, respectively. After 28 days of
administration, the serum of all groups were collected and the hematologic
parameters were assessed. The data were statistically analyzed by ANOVA test.
In all tests, we normally worked with
significance value
of 0.05.
Result: According to the
statistical results, Test group 2 showed a significant decrease in RBC, HCT,
Hb, and MCH in comparison with control
group, while test
groups 3 and 4 showed an enhancement in RBC,
HCT, Hb, and MCV parameters comparing the test group 2.
Conclusion: It is concluded that aqueous-alcoholic extract prangos
ferulacea L. can improve some hematologic incidences including red blood cells,
hemoglobin, and hematocrit.
| Reference Key |
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| Authors | ;Saeedeh Hojabrian;padideh Ebadi;Mokhtar Mokhtari |
| Journal | artificial cells, nanomedicine, and biotechnology |
| Year | 2015 |
| DOI |
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