vitamin a and the nervous system
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ID: 188435
2014
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Abstract
Vitamin A is essential for the early development and normal functioning of
the brain throughout life. A deficiency of vitamin A is one of the leading
causes of morbidity and mortality in developing countries, and subclinical
deficiency is probably present worldwide. The main active molecule in vitamin
A is retinoic acid, which is involved in vision, the immune system, skin
health, olfaction and cognition (learning, memory, spatial functions,
olfaction, etc.) through processes of neuroplasticity and neurogenesis.
Vitamin A is involved in the regulation of about one-sixth of the human
genome. It has non-genomic actions in protein translation and paracrine
actions. Retinal vitamin A aldehyde is crucial for day and night vision. The
best-known manifestation of hypovitaminosis A is night blindness but in more
severe cases, it causes blindness. In the hypothalamus, vitamin A, with
information from the retina, acts in circadian and seasonal regulation.
Increased retinoic acid levels in the blood are associated with increased
risk of depression, and lower levels have been connected with Alzheimer’s
disease, Parkinson’s disease, cerebral ischemia, autistic spectrum disorders
and schizophrenia. Higher doses and longer periods of treatment pose the
threat of hypervitaminosis A. Vitamin A and its analogs are a promising new
class of therapeutic agents in a wide spectrum of disorders, albeit with a
narrow therapeutic window. [Projekat Ministarstva nauke Republike Srbije, br.
175033 i br. 175022]
| Reference Key |
m.2014archivesvitamin
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|---|---|
| Authors | ;Pavlović Dragan M.;Markišić Merdin Š.;Pavlović Aleksandra M.;Lačković Maja M.;Božić Marija M. |
| Journal | gastrointestinal endoscopy |
| Year | 2014 |
| DOI |
10.2298/ABS1404585P
|
| URL | |
| Keywords |
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