expression of p53, p16 and ki67 proteins in ductal adenocarcinoma of the pancreatic head and their relation with survival and cell differentiation

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2010
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Abstract
Objective: To determine the expression of p53, p16 and Ki-67 and its relevance in survival and cell differentiation. Methods: Fifteen duodenopancreatectomized patients were included. Immunohistochemical expression of p53, p16 and Ki-67 was determined in paraffin embedded tumor blocks. The relation of these expressions with different variables was studied. Results: Ninety-three per cent of tumors showed expression of p53 and p16. Ki-67 was expressed in 86.66% of tumors (labeling index – LI 11.91 ± 9.47). The presence of combined alterations was not related to significant differences in tumor type, stage or survival; similar results were obtained analyzing isolated expressions. When groups of p16 and Ki-67 expressions where created, the median survival was not significant. However, there was a slightly better survival in patients with focal expression of p16 (median survival 20.75 versus 14.34), when compared to patients with diffuse expression. Conclusion: The overexpression of p53, p16 and Ki-67 was not related to survival or tumor grade, when comparing isolated or combined expressions.
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Autoren ;Mário Benjamin Goitia-Durán;Marcelo Moura Linhares;Ricardo Artigiani Neto;Franz Robert Apodaca-Torrez;Edson José Lobo;Alberto Goldenberg
Zeitschrift New England Journal of Medicine
Jahr 2010
DOI
DOI nicht gefunden
URL
http://apps.einstein.br/revista/arquivos/PDF/1655-Einsteinv8n4_pg444-448_eng.pdf
Schlüsselwörter
pancreatic neoplasms

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