ticagrelor removal from human blood
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ID: 188305
2017
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Abstract
Summary: The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments. The first set was a first-pass experiment using bovine serum albumin (BSA) solution pre-incubated with ticagrelor, whereas the second set, performed in a recirculating manner, used human blood mixed with ticagrelor. Removal of ticagrelor from BSA solution reached values >99%. The peak removal rate was 99% and 94% from whole blood and 99.99% and 90% from plasma during 10 h and 3 to 4 h of recirculating experiments, respectively. In conclusion, hemadsorption robustly removes ticagrelor from BSA solution and human blood samples. Key Words: concentration, drug, P2Y12, platelet, removal, sorbent, ticagrelor
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| Reference Key |
md2017jacc:ticagrelor
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|---|---|
| Authors | ;George O. Angheloiu, MD;Gabriel B. Gugiu, PhD;Cristian Ruse, PhD;Rishikesh Pandey, PhD;Ramachandra R. Dasari, PhD;Carl Whatling, PhD |
| Journal | journal of nuclear materials |
| Year | 2017 |
| DOI |
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