perils of paediatric anaesthesia and novel molecular approaches: an evidence-based review

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ID: 187924
2015
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Ranked #13 of 138 articles by views in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

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Abstract
Evolution of anaesthesia has been largely helped by progress of evidence-based medicine. In spite of many advancements in anaesthesia techniques and availability of newer and safer drugs, much more needs to be explored scientifically for the development of anaesthesia. Over the last few years, the notion that the actions of the anaesthesiologist have only immediate or short-term consequences has largely been challenged. Evidences accumulated in the recent years have shown that anaesthesia exposure may have long-term consequences particularly in the extremes of ages. However, most of the studies conducted so far are in vitro or animal studies, the results of which have been extrapolated to humans. There have been confounding evidences linking anaesthesia exposure in the developing brain with poor neurocognitive outcome. The results of animal studies and human retrospective studies have raised concern over the potential detrimental effects of general anaesthetics on the developing brain. The purpose of this review is to highlight the long-term perils of anaesthesia in the very young and the potential of improving anaesthesia delivery with the novel molecular approaches.
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bajwa2015indianperils Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sukhminder Jit Singh Bajwa;Smriti Anand;Hemant Gupta
Journal Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
Year 2015
DOI
10.4103/0019-5049.156865
URL
http://www.ijaweb.org/article.asp?issn=0019-5049;year=2015;volume=59;issue=5;spage=272;epage=281;aulast=Bajwa
Keywords
apoptosis brain neurodegeneration general anaesthesia paediatric anaesthesia

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