molecular targeted approaches for advanced braf v600, n-ras, c-kit, and gnaq melanomas
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ID: 186279
2014
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Abstract
The introduction of a newly developed target therapy for metastatic melanomas poses the challenge to have a good molecular stratification of those patients who may benefit from this therapeutic option. Practically, BRAF mutation status (V600E) is commonly screened although other non-V600E mutations (i.e., K-R-M-D) could be found in some patients who respond to therapy equally to the patients harboring V600E mutations. Furthermore, other mutations, namely, N-RAS, KIT, and GNAQ, should be sequenced according to distinct melanoma specific subtypes and clinical aspects. In our report, a practical flow chart is described along with our experience in this field.
| Reference Key |
giovanni2014diseasemolecular
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|---|---|
| Authors | ;Ponti Giovanni;Pellacani Giovanni;Tomasi Aldo;Loschi Pietro;Luppi Gabriele;Gelsomino Fabio;Longo Caterina |
| Journal | international journal of psychology : journal international de psychologie |
| Year | 2014 |
| DOI |
10.1155/2014/671283
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| URL | |
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