role of the neuronal k-cl co-transporter kcc2 in inhibitory and excitatory neurotransmission

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ID: 186018
2012
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Abstract
The K-Cl co-transporter KCC2 plays multiple roles in the physiology of central neurons and alterations of its function and/or expression are associated with several neurological conditions. By regulating intraneuronal chloride homeostasis, KCC2 strongly influences the efficacy and polarity of the chloride-permeable -aminobutyric acid (GABA) type A and glycine receptor (GlyR) mediated synaptic transmission. This appears particularly critical for the development of neuronal circuits as well as for the dynamic control of GABA and glycine signaling in mature networks. The activity of the transporter is also associated with transmembrane water fluxes which compensate solute fluxes associated with synaptic activity. Finally, KCC2 interaction with the actin cytoskeleton appears critical both for dendritic spine morphogenesis and the maintenance of glutamatergic synapses. In light of the pivotal role of KCC2 in the maturation and function of central synapses, it is of particular importance to understand the cellular and molecular mechanisms underlying its regulation. These include development- and activity-dependent modifications both at the transcriptional and post-translational levels. We emphasize the importance of post-translational mechanisms such as phosphorylation and dephosphorylation, oligomerization, cell surface stability, clustering and membrane diffusion for the rapid and dynamic regulation of KCC2 function.
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echamma2012frontiersrole Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ingrid eChamma;Quentin eChevy;Jean Christophe ePoncer;Sabine eLevi
Journal macromolecular bioscience
Year 2012
DOI
10.3389/fncel.2012.00005
URL
http://journal.frontiersin.org/Journal/10.3389/fncel.2012.00005/full
Keywords
spine clustering phosphorylation inhibitory synapses neuropsychiatry biological psychiatry

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