Porous Microstructured Surfaces with pH-Triggered Antibacterial Properties.

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ID: 1860
2019
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Abstract
New antibacterial films are designed with the capability to reversibly regulate their killing and repelling functions in response to variations in environmental pH. These systems consist of porous polystyrene surfaces as the main components and a copolymer bearing pH-sensitive thiazole and triazole groups as the minor components. These pH-sensitive groups, located on the surfaces, can be partially protonated at acidic pH levels, increasing the positive charge density of the surfaces and their antibacterial activity. Similarly, their bacterial adhesion and killing efficiencies in response to changes in pH are evaluated by analyzing the bacterial viability of Staphylococcus aureus bacteria on the surfaces under acidic and neutral pH values. It is demonstrated that after only 1 h of incubation with the bacterial suspension in acidic conditions, the surfaces killed the bacteria, while at pH = 7.4, some of the adhered bacteria are removed. Furthermore, the surface topography exerts an important role by intensifying this response.
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del-campo2019porousmacromolecular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Del Campo, Adolfo;Echeverría, Coro;San Martín, Miguel;Cuervo-Rodríguez, Rocío;Fernández-García, Marta;Muñoz-Bonilla, Alexandra;
Journal macromolecular bioscience
Year 2019
DOI
10.1002/mabi.201900127
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