interleukin-33 receptor (st2) deficiency improves the outcome of staphylococcus aureus-induced septic arthritis
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ID: 185996
2018
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Abstract
The ST2 receptor is a member of the Toll/IL-1R superfamily and interleukin-33 (IL-33) is its agonist. Recently, it has been demonstrated that IL-33/ST2 axis plays key roles in inflammation and immune mediated diseases. Here, we investigated the effect of ST2 deficiency in Staphylococcus aureus-induced septic arthritis physiopathology. Synovial fluid samples from septic arthritis and osteoarthritis individuals were assessed regarding IL-33 and soluble (s) ST2 levels. The IL-33 levels in samples from synovial fluid were significantly increased, whereas no sST2 levels were detected in patients with septic arthritis when compared with osteoarthritis individuals. The intra-articular injection of 1 × 107 colony-forming unity/10 μl of S. aureus American Type Culture Collection 6538 in wild-type (WT) mice induced IL-33 and sST2 production with a profile resembling the observation in the synovial fluid of septic arthritis patients. Data using WT, and ST2 deficient (−/−) and interferon-γ (IFN-γ)−/− mice showed that ST2 deficiency shifts the immune balance toward a type 1 immune response that contributes to eliminating the infection due to enhanced microbicide effect via NO production by neutrophils and macrophages. In fact, the treatment of ST2−/− bone marrow-derived macrophage cells with anti-IFN-γ abrogates the beneficial phenotype in the absence of ST2, which confirms that ST2 deficiency leads to IFN-γ expression and boosts the bacterial killing activity of macrophages against S. aureus. In agreement, WT cells achieved similar immune response to ST2 deficiency by IFN-γ treatment. The present results unveil a previously unrecognized beneficial effect of ST2 deficiency in S. aureus-induced septic arthritis.
| Reference Key |
staurengo-ferrari2018frontiersinterleukin-33
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| Authors | ;Larissa Staurengo-Ferrari;Silvia C. Trevelin;Silvia C. Trevelin;Victor Fattori;Daniele C. Nascimento;Kalil A. de Lima;Jacinta S. Pelayo;Florêncio Figueiredo;Rubia Casagrande;Sandra Y. Fukada;Mauro M. Teixeira;Thiago M. Cunha;Foo Y. Liew;Rene D. Oliveira;Paulo Louzada-Junior;Fernando Q. Cunha;José C. Alves-Filho;Waldiceu A. Verri |
| Journal | sudebno-meditsinskaia ekspertiza |
| Year | 2018 |
| DOI |
10.3389/fimmu.2018.00962
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| URL | |
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