menadione-induced oxidative stress re-shapes the oxylipin profile of aspergillus flavus and its lifestyle

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ID: 185767
2015
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Abstract
Aspergillus flavus is an efficient producer of mycotoxins, particularly aflatoxin B1, probably the most hepatocarcinogenic naturally-occurring compound. Although the inducing agents of toxin synthesis are not unanimously identified, there is evidence that oxidative stress is one of the main actors in play. In our study, we use menadione, a quinone extensively implemented in studies on ROS response in animal cells, for causing stress to A. flavus. For uncovering the molecular determinants that drive A. flavus in challenging oxidative stress conditions, we have evaluated a wide spectrum of several different parameters, ranging from metabolic (ROS and oxylipin profile) to transcriptional analysis (RNA-seq). There emerges a scenario in which A. flavus activates several metabolic processes under oxidative stress conditions for limiting the ROS-associated detrimental effects, as well as for triggering adaptive and escape strategies.
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zaccaria2015toxinsmenadione-induced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Marco Zaccaria;Matteo Ludovici;Simona Marianna Sanzani;Antonio Ippolito;Riccardo Aiese Cigliano;Walter Sanseverino;Marzia Scarpari;Valeria Scala;Corrado Fanelli;Massimo Reverberi
Journal matec web of conferences
Year 2015
DOI
10.3390/toxins7104315
URL
http://www.mdpi.com/2072-6651/7/10/4315
Keywords
oxidative stress oxylipins rna-seq menadione

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